Preparation of Py.SO3 reagent for Parikh-Doering oxidation
One of most popular method for oxidation of alcohol to aldehyde or ketone is Parikh-Doering oxidation (SO3.py/DMSO) and method for preparation of SO3.Py complex was described delow:
Methodology (modified from original method)
To a stirred solution of dry pyridine (64.57 mL, 0.8 mol) in dry CH2Cl2 (150 mL) was added dropwise chlorosulfonic acid (26.3 mL,0.4 mol) over 2 hours. Then, the white percipitate was filterd and washed with ice-cold water (2x100 mL), acetone (50 mL) and ether (50 mL). The resulting precipitate was dired under vacumn.
-SO3PY is sensitive to water.
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Basic Chemistry,Organic Chemistry
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