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Abtract ยืนยันเกี่ยวกับนมและแสงแดด

แม่ไม่ได้รับแสงอาทิตย์ จะทำให้เด็กเกิดมาปัญญาอ่อน

Conception season and cerebral asymmetries among American baseball players: implications for the seasonal birth effect in schizophrenia.
Marzullo G, Fraser FC.
Per Aspera Research Foundation, New York, NY 10023, United States. gmarzullo@prspr.org
Abstract
People with schizophrenia and children born with neural tube defects both tend to be conceived most often in May-June, about a month before the summer solstice, and least often in November-December, a month before the winter solstice. Such timings, coupled with evidence of cerebral asymmetry deficits in schizophrenia, and evidence that asymmetry development and neural tube closure represent concurrent fourth-embryonic-week processes both sensitive to oxidant stress, led us to the hypothesis that pro-oxidant sunlight actions capable of affecting the mother's blood could result in a peri-June peak of inhibition and a peri-December peak of facilitation of both processes. Here, using birth and hand preference data from baseball statistics, we tested the hypothesis's prediction that, as a group representing minimal cerebral lateralization, left-handed players would show the same conception rhythm as that observed in the above disorders. We found that not only strict left-handers (those both batting and throwing left) were most often conceived in May-June but that also strict right-handers and other players denoting more extreme levels of cerebral lateralization were most often conceived in November-December.

การขาดวิตามิน D ทำให้เกิดโรคมะเร็งเต้านม ต่อมลูกหมาก ลำไส้ใหญ่ กระดูก ความดัน เบาหวาน และโรคประสาท
Geographic location and vitamin D synthesis.
Kimlin MG.
Australian Sun and Health Research Laboratory, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia. m.kimlin@qut.edu.au
Abstract
Most of the population receive their nutritional vitamin D requirements through exposure to solar ultraviolet (UV) radiation, with cutaneous synthesis estimated to provide 80-100% of the vitamin D requirements of the body. However, little is understood about the basic interaction of sunlight (UV) exposure and the subsequent photobiology and photochemistry of vitamin D production in humans. Low vitamin D (blood serum 25[OH]D) status has been linked to the development of a surprisingly wide range of diseases. Epidemiological data and animal studies indicate that low vitamin D is linked to rickets, bone mass loss, multiple sclerosis, hypertension, breast cancer, prostate cancer, colorectal cancer, insulin dependent diabetes and schizophrenia. Importantly some this emerging research associates such diseases with location and subsequent ultraviolet radiation exposures. This paper overviews concepts important to consider when assessing the impact of location and UV exposure on vitamin D synthesis.

คนที่อาศัยอยู่ในพื้นที่แสงแดดน้อย มักจะเป็นโรคประสาทและโรคอื่นๆอีกมากมาย
Vitamin D and living in northern latitudes--an endemic risk area for vitamin D deficiency.
Huotari A, Herzig KH.
A I Virtanen Institute for Molecular Sciences, University of Kuopio, Kuopio, Finland.
Abstract
OBJECTIVES: To review the current literature on the health effects of vitamin D, especially the effects on inhabitants living in the northern latitudes. STUDY DESIGN: Literature review. METHODS: The scientific literature concerning health effects of vitamin D was reviewed and the current dietary recommendations for inhabitants living in northern latitudes were discussed. RESULTS: Vitamin D is a steroid-structured hormone produced in the skin upon exposure to UVB-radiation or obtained from certain food products (for example, liver). Its production is mediated by the vitamin D receptor, which belongs to the nuclear receptor family, and exerts its function as a transcription factor regulating several target genes. Active metabolites of vitamin D play an important role in calcium and phosphate homeostasis. Deficiency of vitamin D results in diminished bone mineralization and an increased risk of fractures. In addition, vitamin D is connected to a variety of other diseases that include different cancer types, muscular weakness, hypertension, autoimmune diseases, multiple sclerosis, type 1 diabetes, schizophrenia and depression. CONCLUSIONS: Vitamin D plays a fundamental role in calcium and phosphate homeostasis. A deficiency of vitamin D has been attributed to several diseases. Since its production in the skin depends on exposure to UVB-radiation via the sunlight, the level of vitamin D is of crucial importance for the health of inhabitants who live in the Nordic latitudes where there is diminished exposure to sunlight during the winter season. Therefore, fortification or supplementation of vitamin D is necessary for most of the people living in the northern latitudes during the winter season to maintain adequate levels of circulating 25(OH)D3 to maintain optimal body function and prevent diseases.

คนบ้าในโรงพยาบาลบ้ามักอาการกำเริบในช่วงที่มีแสงน้อย
Annual rhythms of violence in hospitalized affective patients: correlation with changes in the duration of the daily photoperiod.
Roitman G, Orev E, Schreiber G.
Beer Sheva Mental Health Center, Ben Gurion University of the Negev, Israel.
Abstract
We extensively reviewed the medical records of violent patients restrained in a locked psychiatric ward of a university-based hospital for 6 years (1980-1985). A total of 551 patients were restrained at least once during hospitalization, of which 186 patients had affective disorders and 365 had nonaffective psychiatric illnesses. While the number of restrained nonaffective patients was constant throughout the year, the number of restrained affective patients showed a circannual rhythm with nadirs in May and November and peaks in June and December. This pattern of restraints correlated to changes in the length of daily sunlight (photoperiod). These results suggest that the aggressiveness of patients with affective disorders correlates with photoperiod duration and that the aggressiveness of patients with nonaffective disorders does not correlate with photoperiod.

ขาดวิตามิน D จากแสงอาทิตย์แล้วจะเป็นโรคซึมเศร้า
Association between serum 25-hydroxyvitamin D and depressive symptoms in Japanese: analysis by survey season.
Nanri A, Mizoue T, Matsushita Y, Poudel-Tandukar K, Sato M, Ohta M, Mishima N.
Department of Epidemiology and International Health, Research Institute, International Medical Center of Japan, Shinjuku-ku, Tokyo, Japan. nanri@ri.imcj.go.jp
Abstract
Both depressive symptoms and vitamin D insufficiency are common during winter. This study examined the association between serum 25-hydroxyvitamin D and depressive symptoms by survey season. Subjects were 527 municipal employees aged 21-67 years of two municipal offices in Japan. Overall, there was no measurable association. However, in the workplace surveyed in November, multivariate-adjusted odds ratios (95% confidence interval) of having depressive symptoms (Center for Epidemiologic Studies Depression score of >or=16) for the lowest through highest quartiles of serum 25-hydroxyvitamin D were 1.00 (reference), 0.84 (0.45-1.58), 0.83 (0.44-1.58) and 0.59 (0.30-1.15), respectively (trend P=0.14). The association with the severe depressive state was more pronounced. By contrast, there was no such association in the workplace surveyed in July. Overall, this study did not provide evidence linking higher blood vitamin D levels with decreased depressive symptoms. The suggestive inverse association in sun-deprived season warrants further investigation.
วิตามิน D ป้องกันโรคจิต โรคประสาท
Does vitamin D reduce the risk of dementia?
Grant WB.
Sunlight, Nutrition, and Health Research Center (SUNARC), P.O. Box 641603, San Francisco, CA 94164-1603, USA. wbgrant@infionline.net
Abstract
The understanding of the role of vitamin D in maintaining optimal health has advanced sharply in the past two decades. There is mounting evidence for beneficial roles for vitamin D in reducing the risk of bone diseases and fractures, many types of cancer, bacterial and viral infections, autoimmune diseases, and cardiovascular diseases. Recently, several reports have also been published regarding the role of vitamin D in neuroprotection. This article develops the hypothesis that vitamin D can reduce the risk of developing dementia, presenting the evidence from observational and laboratory studies. The observational evidence includes that low serum 25-hydroxyvitamin D [25(OH)D] has been associated with increased risk for cardiovascular diseases, diabetes mellitus, depression, dental caries, osteoporosis, and periodontal disease, all of which are either considered risk factors for dementia or have preceded incidence of dementia. The laboratory evidence includes several findings on the role of vitamin D in neuroprotection and reducing inflammation. Although this evidence is supportive, there do not appear to be observational studies of incidence of dementia with respect to prediagnostic serum 25(OH)D or vitamin D supplementation. Such studies now appear to be warranted.
ขาดวิตามิน D จะเป็นเบาหวาน กระดูกพรุน ฯลฯ
Epidemiology of vitamin D in health and disease.
Wang S.
Department of Clinical Pathology, Cleveland Clinic, Cleveland, OH, USA. wangs2@ccf.org
Abstract
Results from ecological, case-control and cohort studies have shown that vitamin D reduces the risk of bone fracture, falls, autoimmune diseases, type 2 diabetes, CVD and cancer. However, there is still epidemic vitamin D insufficiency especially among individuals living at high latitudes or with dark skin. Serum levels of 25-hydroxyvitamin D (25(OH)D) are considered the best biomarker of vitamin D nutritional status. Appropriate sunshine exposure or oral supplementation is necessary to maintain sufficient vitamin D status, which is generally accepted as serum 25(OH)D>75 nmol/l. Immunoassays, especially RIA, have been primarily used to measure serum 25(OH)D while liquid chromatography-MS (LC-MS) is considered the 'gold standard'. There is significant disparity among the immunoassays, and all immunoassays have considerable bias compared with LC-MS methods. Because of the variations among the results from these different assays, it is necessary that assay-specific reference ranges be established or standardisation of the assays take place. The present review focuses on ecological, case-control, and cohort studies that investigated the role of vitamin D in health and disease. In addition, analytical techniques used in laboratory evaluation of vitamin D nutritional status are also critically reviewed. The majority of the literature included in the present review is selected from that searchable in PubMed up to the end of September 2008.

ขาดวิตามิน D เป็นเบาหวานและโรคอื่นๆ
Modern concepts in the diagnosis and treatment of vitamin D deficiency and its clinical consequences.
Edlich R, Fisher AL, Chase ME, Brock CM, Gubler K, Long WB 3rd.
University of Virginia Health System, Charlottesvill, VA, USA. richardedlich@gmail.com
Abstract
It is the purpose of this comprehensive report to outline a revolutionary strategy to prevent vitamin D deficiency in our nation. Vitamin D is a unique vitamin. Its metabolic product, calcitriol, is a profound secosteroid hormone that has impact on over 1000 genes in the human body. Recent clinical research has implicated vitamin D deficiency as a major factor in the etiology of rickets, a wide variety of cancers, as well as hypertension, stroke, heart attack, diabetes, bone fractures, periodontal disease, and even multiple sclerosis. There are two forms of vitamin D utilized in the human body: D2 and D3. Measurement of 25(OH)D is the most reliable method of detecting vitamin D deficiency. Several methods, including high-performance liquid chromatography (HPLC), chemoluminescence, and radioimmunoassay (RIA), have been developed for the measurement of total 25(OH)D levels. Prevention and treatment of vitamin D deficiency is accomplished by regulated sun exposure as well as vitamin D, supplementation. This information describing our plan to prevent vitamin D deficiency in the patients and employees of Legacy Health System is a landmark accomplishment that should be replicated in every healthcare setting in our country to prevent vitamin D deficiency.

กินนมมากแล้วเป็นโรคจิต schizophrenia และโรคซึมเศร้า เพราะเคซีนในนมทำให้ภูมิคุ้มกันบกพร่อง และไปจับกับเซลล์สมอง
Subunit and whole molecule specificity of the anti-bovine casein immune response in recent onset psychosis and schizophrenia.
Severance EG, Dickerson FB, Halling M, Krivogorsky B, Haile L, Yang S, Stallings CR, Origoni AE, Bossis I, Xiao J, Dupont D, Haasnoot W, Yolken RH.
Stanley Division of Developmental Neurovirology, Department of Pediatrics, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Blalock 1105, Baltimore, MD 21287-4933, United States. eseverance@jhmi.edu
Abstract
Previous studies show increased antibody levels to bovine casein in some individuals with schizophrenia. The immunogenicity of specific domains of bovine casein varies among people with milk sensitivities and thus could vary among different neuropsychiatric disorders. Using ELISAs and immunoblotting, we characterized IgG class antibody specificity to whole bovine casein and to the alpha(s), beta, and kappa subunits in individuals with recent onset psychosis (n=95), long-term schizophrenia (n=103), and non-psychiatric controls (n=65). In both patient groups, we found elevated IgG to casein proteins, particularly to whole casein and the alpha(s) subunit (p
กินนมแล้วเป็นบ้า เพราะสาร BCM 7 ในนมวัวไปจับในสมอง อีกทั้งโรคหัวใจ ปัญญาอ่อน ฯลฯ
Polymorphism of bovine beta-casein and its potential effect on human health.
Kamiński S, Cieslińska A, Kostyra E.
Department of Animal Genetics, University of Warmia and Mazury, M. Oczapowskiego 5, 10-718 Olsztyn, Poland. stachel@uwm.edu.pl
Abstract
Proteins in bovine milk are a common source of bioactive peptides. The peptides are released by the digestion of caseins and whey proteins. In vitro the bioactive peptide beta-casomorphin 7 (BCM-7) is yielded by the successive gastrointestinal proteolytic digestion of bovine beta-casein variants A1 and B, but this was not seen in variant A2. In hydrolysed milk with variant A1 of beta-casein, BCM-7 level is 4-fold higher than in A2 milk. Variants A1 and A2 of beta-casein are common among many dairy cattle breeds. A1 is the most frequent in Holstein-Friesian (0.310-0.660), Ayrshire (0.432-0.720) and Red (0.710) cattle. In contrast, a high frequency of A2 is observed in Guernsey (0.880-0.970) and Jersey (0.490-0.721) cattle. BCM-7 may play a role in the aetiology of human diseases. Epidemiological evidence from New Zealand claims that consumption of beta-casein A1 is associated with higher national mortality rates from ischaemic heart disease. It seems that the populations that consume milk containing high levels of beta-casein A2 have a lower incidence of cardiovascular disease and type 1 diabetes. BCM-7 has also been suggested as a possible cause of sudden infant death syndrome. In addition, neurological disorders, such as autism and schizophrenia, seem to be associated with milk consumption and a higher level of BCM-7. Therefore, careful attention should be paid to that protein polymorphism, and deeper research is needed to verify the range and nature of its interactions with the human gastrointestinal tract and whole organism.

Create Date : 22 เมษายน 2553

Last Update : 22 เมษายน 2553 13:35:02 น.

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