นี่คือส่วนหนึ่งที่เอามาจากการหาข้อมูลที่ทำให้คิดว่า IGF-I มีความสัมพันธ์ breast cancer
//cebp.aacrjournals.org/cgi/content/abstract/15/12/2489 Insulin-like Growth Factor I in Pregnancy and Maternal Risk of Breast Cancer Annekatrin Lukanova1,3, Paolo Toniolo1,2, Anne Zeleniuch-Jacquotte2, Kjell Grankvist4, Marianne Wulff5, Alan A. Arslan1,2, Yelena Afanasyeva2, Robert Johansson6, Per Lenner7, Göran Hallmans3, Göran Wadell8 and Eva Lundin4 Departments of 1 Obstetrics and Gynecology and 2 Environmental Medicine, New York University School of Medicine, New York, New York; and Departments of 3 Public Health and Clinical Medicine/Nutritional Research, 4 Medical Biosciences, 5 Clinical Sciences, 6 Oncology, 7 Radiation Sciences, and 8 Clinical Microbiology, University of Umeå, Umeå, Sweden Ren, Yuping; Wu, Yiping. Insulin-like growth factor- I and breast cancer. Yixue Fenzi Shengwuxue Zazhi (2006), 3(4), 309-312. CODEN: YFSZAO ISSN:1672-8009. AN 2006:1162406 CAPLUS
The aim of this study was to examine the relationship of diet with serum insulin-like growth factor-I (IGF-I) and IGF-binding protein-3 in women. Design: Cross-sectional study. Setting and subjects: The population are 2109 women who were control subjects in a casecontrol study of breast cancer nested in the European Prospective Investigation into Cancer and Nutrition. Control subjects were randomly chosen among risk sets consisting of female cohort members alive and free of cancer (except non-melanoma skin cancer) at the time of diagnosis of the index case. Matching criteria were age at enrolment, follow-up time, time of the day of blood collection and study centre. Diet was measured through validated questionnaires. Serum hormone concentrations were measured by enzyme-linked immunosorbent assays. The relationship between serum IGF-I, IGFBP-3, and intake of nutrients and foods was explored by linear regression in models adjusted for energy intake, age, body mass index, smoking, physical activity, centre and laboratory batch. Results: Serum IGF-I levels were positively related to protein intake (P trend<0.001), but not related to energy, fat or carbohydrate intake. Positive relationships were observed with the intake of milk (P trend=0.007), calcium (P trend<0.001), magnesium (P trend=0.003), phosphorus (P trend<0.001), potassium (P trend=0.002), vitamin B6 (P trend=0.03), vitamin B2 (P trend=0.001) and inverse relationships with vegetables (P trend=0.02) and beta-carotene (P trend=0.02). IGFBP-3 was not related with most of the nutrients and foods in this study. Conclusions: In this population, circulating IGF-I is modestly related with the intake of protein and minerals, and with milk and cheese, while IGFBP-3 does not appear to be related with diet.
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โดย: law of nature วันที่: 16 มกราคม 2550 เวลา:21:14:13 น.
I am more convinced than ever that drinking milk will cause cancer to grow much faster in your body than it would without the added additional IGF-I hormone. I would like to thank Robert Cohen of Notmilk.com for this brief and easy to understand summary of why drinking milk can aid in the growth of cancer. There are hundreds of millions of different proteins on Earth, and only one hormone is known to be identical between any two completely different species. That powerful growth hormone is insulin-like growth factor, or IGF-I. IGF-I survives digestion and has been identified as the KEY FACTOR in breast cancer's growth. IGF-I is identical in human and cow. If you believe that breast feeding "works" to protect lactoferrins and immunoglobulins from digestion (and benefit the nursing infant), you must also recognize that milk is a hormonal delivery system. By drinking cow's milk, one delivers IGF-I in a bioactive form to the body's cells. When IGF-I from cow's milk alights upon an existing cancer. "Human Insulin-like growth factor (IGF-I) and bovine IGF-I are identical. Both contain 70 amino acids in the identical sequence." Judith C. Juskevich and C. Greg Guyer. SCIENCE, vol. 249. August 24, 1990. "IGF-I is critically involved in the aberrant growth of human breast cancer cells." M. Lippman. J. Natl. Inst. Health Res., 1991, 3. "Estrogen regulation of IGF-I in breast cancer cells would support the hypothesis that IGF-I has a regulatory function in breast cancer." A.V. Lee, Mol-Cell- Endocrinol., March, 99(2). "IGF-I is a potent growth factor for cellular proliferation in the human breast carcinoma cell line." J.C. Chen, J-Cell-Physiol., January, 1994, 158(1) "Insulin-like growth factors are key factors for breast cancer growth." J.A. Figueroa, J-Cell-Physiol., Nov., 1993, 157(2) "IGF-I produces a 10-fold increase in RNA levels of cancer cells. IGF-I appears to be a critical component in cellular proliferation." X.S. Li, Exp-Cell-Res., March, 1994, 211(1) "IGF-I plays a major role in human breast cancer cell growth." E.A. Musgrove, Eur-J-Cancer, 29A (16), 1993 "IGF-I has been identified as a key factor in breast cancer." Hankinson. The Lancet, vol. 351. May 9, 1998 "Serum IGF-I levels increased significantly in milk drinkers, an increase of about 10% above baseline but was unchanged in the control group." Robert P. Heaney, Journal of the American Dietetic Association, vol. 99, no. 10. October 1999 "IGF-1 accelerates the growth of breast cancer cells." M. Lippman Science, Vol. 259, January 29, 1993
แต่ที่ผมเขียนมาเสมอๆคือ ไม่มีแม้แต่ paper เดียวที่จะฟันธงได้ว่า การกินนมจะทำให้เกิดมะเร็ง '''แม้แต่เพิ่ม IGF-1 ยังไม่มี paper ที่น่าเชื่อถือเลยครับ'' ---Serum IGF-I levels were positively related to protein intake (P trend<0.001), but not related to energy, fat or carbohydrate intake. Positive relationships were observed with the intake of milk >>> In this population, circulating IGF-I is modestly related with the intake of protein and minerals, and with milk and cheeseกับการบริโภคนมหรือไม่
In this population, circulating IGF-I is modestly related with the intake of protein and minerals, and with milk and cheese>>เกี่ยวอาหาร และนมวัว
โดย: law of nature IP: 81.106.200.74 วันที่: 22 มกราคม 2550 เวลา:5:20:44 น.
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