Preparation of Py.SO3 reagent for Parikh-Doering oxidation

         One of most popular method for oxidation of alcohol to aldehyde or ketone is Parikh-Doering oxidation (SO3.py/DMSO) and method for preparation of SO3.Py complex was described delow:


Chemical reagents

-Chlorosulfonic acid

-dry Pyridine

-dry CH2Cl2

Methodology (modified from original method)

         To a stirred solution of  dry pyridine (64.57 mL, 0.8 mol) in dry CH2Cl2 (150 mL) was added dropwise chlorosulfonic acid (26.3 mL,0.4 mol) over 2 hours. Then, the white percipitate was filterd and washed with ice-cold water (2x100 mL), acetone (50 mL) and ether (50 mL).  The resulting precipitate was dired under vacumn.


Note


-SO3PY is sensitive to water.


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Create Date : 03 กรกฎาคม 2554
Last Update : 3 กรกฎาคม 2554 15:36:49 น.
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Basic Chemistry,Organic Chemistry